An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.

An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.

ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins - Dpb11(TopBP1), Ddc1(Rad9) and Dna2 - all interact with and activate Mec1(ATR). Each contains an ATR activation domain (ADD) that interacts directly with the Mec1(ATR):...

Full description

Bibliographic Details
Main Authors: Zhong-Wei Zhou, Cong Liu, Tang-Liang Li, Christopher Bruhn, Anja Krueger, WooKee Min, Zhao-Qi Wang, Antony M Carr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3738440?pdf=render

Internet

http://europepmc.org/articles/PMC3738440?pdf=render

Similar Items