An Unexpected Enzyme in Vascular Smooth Muscle Cells: Angiotensin II Upregulates Cholesterol-25-Hydroxylase Gene Expression

An Unexpected Enzyme in Vascular Smooth Muscle Cells: Angiotensin II Upregulates Cholesterol-25-Hydroxylase Gene Expression

Angiotensin II (AngII) is a vasoactive peptide hormone, which, under pathological conditions, contributes to the development of cardiovascular diseases. Oxysterols, including 25-hydroxycholesterol (25-HC), the product of cholesterol-25-hydroxylase (CH25H), also have detrimental effects on vascular h...

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Bibliographic Details
Main Authors: Kinga Bernadett Kovács, Laura Szalai, Pál Szabó, Janka Borbála Gém, Szilvia Barsi, Bence Szalai, Bernadett Perey-Simon, Gábor Turu, András Dávid Tóth, Péter Várnai, László Hunyady, András Balla
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
angiotensin II
atherosclerosis
cholesterol-25-hydroxylase
25-hydroxycholesterol
vascular smooth muscle cell
Online Access:https://www.mdpi.com/1422-0067/24/4/3968

Internet

https://www.mdpi.com/1422-0067/24/4/3968

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