Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression

Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression

We developed a novel lentiviral vector, pseudotyped with the F and HN proteins from Sendai virus (rSIV.F/HN), that produces long-lasting, high-efficiency transduction of the respiratory epithelium. Here we addressed whether this platform technology can secrete sufficient levels of a therapeutic prot...

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Bibliographic Details
Main Authors: Helena Lund-Palau, Claudia Ivette Juarez-Molina, Cuixiang Meng, Anushka Bhargava, Aikaterini Pilou, Kiran Aziz, Nora Clarke, Naoko Atsumi, Ali Ashek, Michael R. Wilson, Masao Takata, Simon Padley, Deborah R. Gill, Stephen C. Hyde, Cliff Morgan, Eric W.F.W. Alton, Uta Griesenbach
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
autoimmune pulmonary alveolar proteinosis
PAP
alveolar macrophage
surfactant protein
granulocyte-macrophage colony-stimulating factor
GM-CSF
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000493

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http://www.sciencedirect.com/science/article/pii/S2329050122000493

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