Phylogenomics of Cas4 family nucleases

Abstract Background The Cas4 family endonuclease is a component of the adaptation module in many variants of CRISPR-Cas adaptive immunity systems. Unlike most of the other Cas proteins, Cas4 is often encoded outside CRISPR-cas loci (solo-Cas4) and is also found in mobile genetic elements (MGE-Cas4)....

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Bibliographic Details
Main Authors: Sanjarbek Hudaiberdiev, Sergey Shmakov, Yuri I. Wolf, Michael P. Terns, Kira S. Makarova, Eugene V. Koonin
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Evolutionary Biology
Online Access:http://link.springer.com/article/10.1186/s12862-017-1081-1