Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action

Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action

Novel pyrazolo[3,4-d] pyrimidine derivatives bearing carbon-aryl(heteryl)idene moieties were synthesized via a condensation reaction of 5-aminopyrazoles and cyclic lactams. The preparation of the target compounds employed bioisosterism, where a pyrazole ring was a major replacement. Fifteen target c...

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Bibliographic Details
Main Authors: Zukela Ruzi, Khurshed Bozorov, Lifei Nie, Jiangyu Zhao, Haji Akber Aisa
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pyrazolo[3,4-d]pyrimidinone
Pyrimidine
in vivo anticancer activity
HT-29 cells
VEGFR-2, tubulin polymerization
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013373

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http://www.sciencedirect.com/science/article/pii/S0753332222013373

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