Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation

Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation

Abstract Early embryonic arrest and fragmentation (EEAF) is a common phenomenon leading to female infertility, but the genetic determinants remain largely unknown. The Moloney sarcoma oncogene (MOS) encodes a serine/threonine kinase that activates the ERK signaling cascade during oocyte maturation i...

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Bibliographic Details
Main Authors: Yin‐Li Zhang, Wei Zheng, Peipei Ren, Huiling Hu, Xiaomei Tong, Shuo‐Ping Zhang, Xiang Li, Haichao Wang, Jun‐Chao Jiang, Jiamin Jin, Weijie Yang, Lanrui Cao, Yuanlin He, Yerong Ma, Yingyi Zhang, Yifan Gu, Liang Hu, Keli Luo, Fei Gong, Guang‐Xiu Lu, Ge Lin, Heng‐Yu Fan, Songying Zhang
Format: Article
Language:English
Published: Springer Nature 2021-12-01
Series:EMBO Molecular Medicine
Subjects:
female infertility
human oocyte
maternal mRNA decay
mitochondria
MOS
Online Access:https://doi.org/10.15252/emmm.202114887

Internet

https://doi.org/10.15252/emmm.202114887

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