The Lack of the TetR-Like Repressor Gene BCG_2177c (Rv2160A) May Help Mycobacteria Overcome Intracellular Redox Stress and Survive Longer Inside Macrophages When Surrounded by a Lipid Environment

The Lack of the TetR-Like Repressor Gene BCG_2177c (Rv2160A) May Help Mycobacteria Overcome Intracellular Redox Stress and Survive Longer Inside Macrophages When Surrounded by a Lipid Environment

Mycobacteria, like other microorganisms, survive under different environmental variations by expressing an efficient adaptive response, oriented by regulatory elements, such as transcriptional repressors of the TetR family. These repressors in mycobacteria also appear to be related to cholesterol me...

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Bibliographic Details
Main Authors: Lázaro García-Morales, Patricia Del Portillo, Juan M. Anzola, Miguel A. Ares, Addy C. Helguera-Repetto, Jorge F. Cerna-Cortes, Alfonso Méndez-Tenorio, María J. García, Isabel Otal, Carlos Martín, Jorge A. Gonzalez-y-Merchand, Sandra Rivera-Gutiérrez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
BCG_2177c gene
TetR family
lipid environment
gene expression
transcriptomics by RNAseq
macrophages response
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.907890/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.907890/full

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