The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability

The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability

Interleukin-2 is central to the induction and maintenance of both natural (nT<sub>reg</sub>) and induced Foxp3-expressing regulatory T cells (iT<sub>reg</sub>). Thus, signals that modulate IL-2 availability may, in turn, also influence T<sub>reg</sub> homeostasis....

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Bibliographic Details
Main Authors: Bernd Geers, Julia Hagenstein, Jessica Endig, Hanna Ulrich, Laura Fleig, Paulina Sprezyna, Julita Mikulec, Lukas Heukamp, Gisa Tiegs, Linda Diehl
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
regulatory T cell
Foxp3
pSTAT5
interleukin 2
Arl4d
immune regulation
Online Access:https://www.mdpi.com/2073-4409/11/17/2639

Internet

https://www.mdpi.com/2073-4409/11/17/2639

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