Arginine Dysregulation and Myocardial Dysfunction in a Mouse Model and Children with Chronic Kidney Disease

Cardiovascular disease is the leading cause of death in chronic kidney disease (CKD). Arginine, the endogenous precursor for nitric oxide synthesis, is produced in the kidneys. Arginine bioavailability contributes to endothelial and myocardial dysfunction in CKD. Plasma from 129X1/SvJ mice with and...

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Bibliographic Details
Main Authors: Loretta Z. Reyes, Pamela D. Winterberg, Roshan Punnoose George, Michael Kelleman, Frank Harris, Hanjoong Jo, Lou Ann S. Brown, Claudia R. Morris
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/15/9/2162