Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.

Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.

The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) localize to both cilia and EVs, act in the same geneti...

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Bibliographic Details
Main Authors: Jonathon D Walsh, Juan Wang, Molly DeHart, Inna A Nikonorova, Jagan Srinivasan, Maureen M Barr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010560

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https://doi.org/10.1371/journal.pgen.1010560

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