Dysfunction of Cytotoxic T Lymphocyte Induced by Hepatoma Cells through the Gln-GLS2-Endoplasmic Reticulum Stress Pathway

Dysfunction of Cytotoxic T Lymphocyte Induced by Hepatoma Cells through the Gln-GLS2-Endoplasmic Reticulum Stress Pathway

Background: Metabolic activities of tumor cells lead to a depletion of nutrients within the tumor microenvironment, which results in the dysfunction of infiltrating T cells. Here, we explored how glutamine (gln) metabolism, which is essential for biosynthesis and cellular function, can affect the fu...

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Bibliographic Details
Main Authors: Wei Wang, Mengnan Guo, Zekun Bai, Wen Bai, Weixi Chen, Yali Su, Jinghua Wu
Format: Article
Language:English
Published: IMR Press 2022-08-01
Series:Frontiers in Bioscience-Landmark
Subjects:
ctls
dysfunction
glutamine
gls2
endoplasmic reticulum stress
Online Access:https://www.imrpress.com/journal/FBL/27/8/10.31083/j.fbl2708243

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https://www.imrpress.com/journal/FBL/27/8/10.31083/j.fbl2708243

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