Dysfunction of Cytotoxic T Lymphocyte Induced by Hepatoma Cells through the Gln-GLS2-Endoplasmic Reticulum Stress Pathway
Background: Metabolic activities of tumor cells lead to a depletion of nutrients within the tumor microenvironment, which results in the dysfunction of infiltrating T cells. Here, we explored how glutamine (gln) metabolism, which is essential for biosynthesis and cellular function, can affect the fu...
Main Authors: | Wei Wang, Mengnan Guo, Zekun Bai, Wen Bai, Weixi Chen, Yali Su, Jinghua Wu |
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Format: | Article |
Language: | English |
Published: |
IMR Press
2022-08-01
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Series: | Frontiers in Bioscience-Landmark |
Subjects: | |
Online Access: | https://www.imrpress.com/journal/FBL/27/8/10.31083/j.fbl2708243 |
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