Epigenetic Silencing of the Protocadherin Family Member PCDH-γ-All in Astrocytomas

Epigenetic Silencing of the Protocadherin Family Member PCDH-γ-All in Astrocytomas

In a microarray-based methylation analysis of astrocytomas [World Health Organization (WHO) grade II], we identified a CpG island within the first exon of the protocadherin-γ subfamily A11 (PCDH-γ-A11) gene that showed hypermethylation compared to normal brain tissue. Bisulfite sequencing and combin...

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Bibliographic Details
Main Authors: Anke Waha, Stefanie Güntner, Tim Hui-Ming Huang, Pearlly S. Yan, Bülent Arslan, Torsten Pietsch, Otmar D. Wiestler, Andreas Waha
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Glioma
PCDH-γ-A11
methylation
cRT-PCR
expression
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860580020X

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http://www.sciencedirect.com/science/article/pii/S147655860580020X

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