Ectodysplasin A1 Deficiency Leads to Osteopetrosis-like Changes in Bones of the Skull Associated with Diminished Osteoclastic Activity

Ectodysplasin A1 Deficiency Leads to Osteopetrosis-like Changes in Bones of the Skull Associated with Diminished Osteoclastic Activity

Pathogenic variants of the gene <i>Eda</i> cause X-linked hypohidrotic ectodermal dysplasia (XLHED), which is characterized by structural abnormalities or lack of ectodermal appendages. Signs of dysplasia are not restricted to derivatives of the ectodermal layer, but mesodermal abnormali...

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Bibliographic Details
Main Authors: Christine Schweikl, Sigrun Maier-Wohlfart, Holm Schneider, Jung Park
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
bone
ectodysplasin A1
ectodermal dysplasia
osteopetrosis
osteoclast differentiation
NF-κB
Online Access:https://www.mdpi.com/1422-0067/23/20/12189

Internet

https://www.mdpi.com/1422-0067/23/20/12189

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