Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

Abstract Background Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contributes to development of oxaliplatin resistance. Aberrant expression of...

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Bibliographic Details
Main Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun, Chuanxin Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Cancer
Subjects:
miR-218-3p
Exosome
Colorectal cancer
Chemoresistance
Epithelial-mesenchymal transition
Drug efflux
Online Access:http://link.springer.com/article/10.1186/s12943-019-0981-7

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http://link.springer.com/article/10.1186/s12943-019-0981-7

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