A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens

A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens

A key aspect to finding an efficacious human immunodeficiency virus (HIV) vaccine is the optimization of vaccine schedules that can mediate the efficient maturation of protective immune responses. In the present study, we investigated the effect of alternate booster regimens on the immune responses...

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Bibliographic Details
Main Authors: Sven Kratochvil, Paul F. McKay, Jakub T. Kopycinski, Cynthia Bishop, Peter John Hayes, Luke Muir, Christopher L. Pinder, Deniz Cizmeci, Deborah King, Yoann Aldon, Bruce D. Wines, P. Mark Hogarth, Amy W. Chung, Stephen J. Kent, Kathrin Held, Christof Geldmacher, Len Dally, Nelson S. Santos, Tom Cole, Jill Gilmour, Sarah Fidler, Robin J. Shattock
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
IgG subclasses
vaccine interval
human immunodeficiency virus vaccine
adjuvant
homologous prime-boost strategy
human immunodeficiency virus envelope protein
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00595/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00595/full

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