Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source

Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source

NBSGW mice are highly immunodeficient and carry a hypomorphic mutation in the c-kit gene, providing a host environment that supports robust human hematopoietic expansion without pre-conditioning. These mice thus provide a model to investigate human hematopoietic engraftment in the absence of conditi...

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Bibliographic Details
Main Authors: Nicholas J. Hess, Payton N. Lindner, Jessica Vazquez, Samuel Grindel, Amy W. Hudson, Aleksandar K. Stanic, Akihiro Ikeda, Peiman Hematti, Jenny E. Gumperz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
human immune system mice
HSC
HPSC
c-KIT mutation
bone marrow
umbilical cord blood
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.573406/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.573406/full

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