The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2α Phosphorylation and Stress Granule Formation

The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2α Phosphorylation and Stress Granule Formation

Sindbis virus (SINV) infection induces eIF2α phosphorylation, which leads to stress granule (SG) assembly. SINV infection also stimulates autophagy, which has an important role in controlling the innate immune response. The importance of autophagy to virus-induced translation arrest is not...

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Bibliographic Details
Main Authors: Matthew Jefferson, Benjamin Bone, Jasmine L. Buck, Penny P. Powell
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Viruses
Subjects:
sindbis virus
eif2α
autophagy
stress granule
interferon
rna binding proteins
Online Access:https://www.mdpi.com/1999-4915/12/1/39

Internet

https://www.mdpi.com/1999-4915/12/1/39

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