Evaluation of the Spider (<i>Phlogiellus</i> genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Evaluation of the Spider (<i>Phlogiellus</i> genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na<sub>V</sub>1.7 subtype of voltage-g...

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Bibliographic Details
Main Authors: Tânia C. Gonçalves, Pierre Lesport, Sarah Kuylle, Enrico Stura, Justyna Ciolek, Gilles Mourier, Denis Servent, Emmanuel Bourinet, Evelyne Benoit, Nicolas Gilles
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
<i>Phlogiellus</i> spider
phlotoxin 1
human voltage-gated ion channel subtypes
Na<sub>V</sub>1.7 channel subtype
mouse model of Na<sub>V</sub>1.7-mediated pain
Online Access:https://www.mdpi.com/2072-6651/11/9/484

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https://www.mdpi.com/2072-6651/11/9/484

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