Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models

Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models

Abstract Alzheimer’s disease (AD) is characterized by genetic and multifactorial risk factors. Many studies correlate AD to sleep disorders. In this study, we performed and validated a mouse model of AD and sleep fragmentation, which properly mimics a real condition of intermittent awakening. We not...

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Bibliographic Details
Main Authors: Valeria Vasciaveo, Antonella Iadarola, Antonino Casile, Davide Dante, Giulia Morello, Lorenzo Minotta, Elena Tamagno, Alessandro Cicolin, Michela Guglielmotto
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Sleep fragmentation
Aquaporin-4 channel
Amyloid-β
p-tau
Neuroinflammation
Online Access:https://doi.org/10.1186/s40478-022-01498-2

Internet

https://doi.org/10.1186/s40478-022-01498-2

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