Host and immunosuppression-related factors influencing fibrosis occurrence post liver transplantation

Host and immunosuppression-related factors influencing fibrosis occurrence post liver transplantation

Post liver transplantation (LT) fibrosis has a negative impact on graft function. Cytokine production in the host immune response after LT may contribute to the variable CYP3A-dependent immunosuppressive drug disposition, with subsequent impact on liver fibrogenesis, together with host-related facto...

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Bibliographic Details
Main Authors: Speranta Iacob, Razvan Iacob, Ioana Manea, Mihaela Uta, Andrei Chiosa, Mona Dumbrava, Gabriel Becheanu, Luminita Stoica, Codruta Popa, Vlad Brasoveanu, Doina Hrehoret, Cristian Gheorghe, Liana Gheorghe, Simona Dima, Irinel Popescu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
graft fibrosis
tacrolimus
mycophenolate mofetil
CYP3A5 genotype
apoptosis
hepatocytes culture
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1042664/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1042664/full

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