Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice.

Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice.

Skeletal muscle nNOSmu (neuronal nitric oxide synthase mu) localizes to the sarcolemma through interaction with the dystrophin-associated glycoprotein (DAG) complex, where it synthesizes nitric oxide (NO). Disruption of the DAG complex occurs in dystrophinopathies and sarcoglycanopathies, two geneti...

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Bibliographic Details
Main Authors: Justin M Percival, Kendra N E Anderson, Paul Gregorevic, Jeffrey S Chamberlain, Stanley C Froehner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2559862?pdf=render

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http://europepmc.org/articles/PMC2559862?pdf=render

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