Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

<p>Abstract</p> <p>Background</p> <p>Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of both signaling pathways, alone and in combination, in reducing the growth...

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Bibliographic Details
Main Authors: Liu Ren, Silva Lilliana, Badenes Marina, Gigante Joana, Trindade Alexandre, Djokovic Dusan, Li Xiuqing, Gong Ming, Krasnoperov Valery, Gill Parkash S, Duarte Antonio
Format: Article
Language:English
Published: BMC 2010-11-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/641

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http://www.biomedcentral.com/1471-2407/10/641

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