Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also creates a gradient of lactate that mirrors the gra...

Full description

Bibliographic Details
Main Authors: Pierre Sonveaux, Tamara Copetti, Christophe J De Saedeleer, Frédérique Végran, Julien Verrax, Kelly M Kennedy, Eui Jung Moon, Suveera Dhup, Pierre Danhier, Françoise Frérart, Bernard Gallez, Anthony Ribeiro, Carine Michiels, Mark W Dewhirst, Olivier Feron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3302812?pdf=render

Internet

http://europepmc.org/articles/PMC3302812?pdf=render

Similar Items