Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Abstract: In humans, platelet count within the normal range is required for physiological hemostasis, but, adversely, platelets also support pathological thrombosis. Moreover, by releasing growth factors, they may enhance neoplastic proliferation. We hypothesize that platelet count correlates with p...

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Main Authors: Toshiaki Shirai, Alexey S. Revenko, Justin Tibbitts, Anh T.P. Ngo, Annachiara Mitrugno, Laura D. Healy, Jennifer Johnson, Erik I. Tucker, Monica T. Hinds, Lisa M. Coussens, Owen J.T. McCarty, Brett P. Monia, András Gruber
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920318280

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http://www.sciencedirect.com/science/article/pii/S2473952920318280

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