Varenicline improves cognitive impairment in a mouse model of mPFC ischemia: The possible roles of inflammation, apoptosis, and synaptic factors

Varenicline improves cognitive impairment in a mouse model of mPFC ischemia: The possible roles of inflammation, apoptosis, and synaptic factors

Ischemia in the medial prefrontal cortex (mPFC) causes cognitive impairment in stroke cases. This study aimed to examine the effects of varenicline as α7 and α4β2 nicotine acetylcholine receptors (nAChRs) agonist, on cognitive impairment, inflammation, apoptosis, and synaptic dysfunction in mPFC isc...

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Bibliographic Details
Main Authors: Fatemehsadat Seyedaghamiri, Leila Hosseini, Sareh Kazmi, Javad Mahmoudi, Dariush Shanehbandi, Abbas Ebrahimi-Kalan, Reza Rahbarghazi, Saeed Sadigh-Eteghad, Mehdi Farhoudi
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Brain Research Bulletin
Subjects:
Brain ischemia
Varenicline
Medial prefrontal cortex
Memory
Anxiety
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022000144

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http://www.sciencedirect.com/science/article/pii/S0361923022000144

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