Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial
Abstract Purpose The early identification of maximum tolerated dose (MTD) in phase I trial leads to faster progression to a phase II trial or an expansion cohort to confirm efficacy. Methods We propose a novel adaptive design for identifying MTD early to accelerate dose-finding trials. The early ide...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Medical Research Methodology |
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| Online Access: | https://doi.org/10.1186/s12874-022-01584-y |