Carbamylated Erythropoietin Decreased Proliferation and Neurogenesis in the Subventricular Zone, but Not the Dentate Gyrus, After Irradiation to the Developing Rat Brain

Carbamylated Erythropoietin Decreased Proliferation and Neurogenesis in the Subventricular Zone, but Not the Dentate Gyrus, After Irradiation to the Developing Rat Brain

Cranial radiotherapy for pediatric brain tumors causes progressive, debilitating late effects, including cognitive decline. Erythropoietin (EPO) has been shown to be neuroprotective and to promote neuroregeneration. Carbamylated erythropoietin (CEPO) retains the protective properties of EPO but is n...

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Bibliographic Details
Main Authors: Kazuhiro Osato, Yoshiaki Sato, Akari Osato, Machiko Sato, Changlian Zhu, Marcel Leist, Hans G. Kuhn, Klas Blomgren
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neurology
Subjects:
radiotherapy
pediatric oncology
late effects
immature brain
neural stem cell
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00738/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00738/full

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