Development of an alginate-Matrigel hydrogel system to evaluate cancer cell behavior in the stiffness range of the bone marrow

Bone metastasis is highly prevalent in breast cancer patients with metastatic disease. These metastatic cells may eventually form osteolytic lesions and affect the integrity of the bone, causing pathological fractures and impairing patient quality of life. Although some mechanisms have been determin...

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Bibliographic Details
Main Authors: Logan A. Northcutt, Alyssa M. Questell, Julie Rhoades, Marjan Rafat
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Biomaterials Science
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbiom.2023.1140641/full