Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution

Characterizing interactions of Synaptotagmin‐1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X‐ray crystallography revealed how the Synaptotagmin‐1 C2B domain binds to the SNARE complex through a so‐called primary interface and to a complexin‐1‐SNARE comp...

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Bibliographic Details
Main Authors: Klaudia Jaczynska, Luis Esquivies, Richard A. Pfuetzner, Baris Alten, Kyle D. Brewer, Qiangjun Zhou, Ege T. Kavalali, Axel T. Brunger, Josep Rizo
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:FEBS Open Bio
Subjects:
Ca2+ sensing
complexin
neurotransmitter release
SNAREs
synaptotagmin
weak protein interactions
Online Access:https://doi.org/10.1002/2211-5463.13503

Internet

https://doi.org/10.1002/2211-5463.13503

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