A New Cell Model for Investigating Prion Strain Selection and Adaptation

A New Cell Model for Investigating Prion Strain Selection and Adaptation

Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes. Host-strain interactions result in the selective damage of distinct brain areas a...

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Bibliographic Details
Main Authors: Alexandra Philiastides, Juan Manuel Ribes, Daniel Chun-Mun Yip, Christian Schmidt, Iryna Benilova, Peter-Christian Klöhn
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
prions
prion strains
neurodegeneration
selective neuronal vulnerability
adaptation
prion propagation
astrocytes
neurons
Online Access:https://www.mdpi.com/1999-4915/11/10/888

Internet

https://www.mdpi.com/1999-4915/11/10/888

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