Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for <i>EYS</i>-Associated Retinitis Pigmentosa

Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for <i>EYS</i>-Associated Retinitis Pigmentosa

Retinitis pigmentosa (RP) is an inherited retinal disease (IRD) with an overall prevalence of 1 in 4000 individuals. Mutations in <i>EYS</i> (<i>Eyes shut homolog</i>) are among the most frequent causes of non-syndromic autosomal recessively inherited RP and act via a loss-of...

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Bibliographic Details
Main Authors: Renske Schellens, Erik de Vrieze, Pam Graave, Sanne Broekman, Kerstin Nagel-Wolfrum, Theo Peters, Hannie Kremer, Rob W. J. Collin, Erwin van Wijk
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
<i>EYS</i>
CRISPR/Cas9
antisense oligonucleotides
exon skipping therapy
photoreceptors
retinitis pigmentosa
Online Access:https://www.mdpi.com/1422-0067/22/17/9154

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https://www.mdpi.com/1422-0067/22/17/9154

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