HLA-DR+ Immature Cells Exhibit Reduced Antigen-Presenting Cell Function But Respond to CD40 Stimulation

HLA-DR+ Immature Cells Exhibit Reduced Antigen-Presenting Cell Function But Respond to CD40 Stimulation

Dendritic cells (DC) have been implicated in the defective function of the immune system during cancer progression. We have demonstrated that patients with cancer have fewer myeloid (CD11c+) and plasmacytoid (CD123hi) DC and a concurrent accumulation of CD11c−CD123− immature cells expressing HLA-DR...

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Bibliographic Details
Main Authors: Alberto Pinzon-Charry, Tammy Maxwell, Sandro Prato, Colin Furnival, Chris Schmidt, José Alejandro López
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Antigen-presenting cell
dendritic cell subsets
CD40 ligand
apoptosis
immune dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800491

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http://www.sciencedirect.com/science/article/pii/S1476558605800491

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