5-Nitroisoxazoles in <i>S<sub>N</sub>Ar</i> Reactions: A Novel Chemo- and Regioselective Approach to Isoxazole-Based Bivalent Ligands of AMPA Receptors

5-Nitroisoxazoles in <i>S<sub>N</sub>Ar</i> Reactions: A Novel Chemo- and Regioselective Approach to Isoxazole-Based Bivalent Ligands of AMPA Receptors

An efficient regioselective approach to novel functionalized bis(isoxazoles) with a variety of aromatic and aliphatic linkers was elaborated, based on the heterocyclization reaction of electrophilic alkenes under the treatment with tetranitromethane-triethylamine complex affording 3-EWG-5-nitroisoxa...

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Bibliographic Details
Main Authors: Dmitry A. Vasilenko, Nadezhda S. Temnyakova, Sevastian E. Dronov, Eugene V. Radchenko, Yuri K. Grishin, Alexey V. Gabrel’yan, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Elena B. Averina, Vladimir A. Palyulin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
heterocyclization
regioselective
tetranitromethane
isoxazole
bivalent ligand
AMPA receptor
Online Access:https://www.mdpi.com/1422-0067/24/22/16135

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https://www.mdpi.com/1422-0067/24/22/16135

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