Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase.

Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase.

Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein-protein interactions; however, its relevance to disease processes is not clear. Using a genome-wide, phenotype driven N-ethyl-N-nitrosourea-mediated mutagenesis screen, we identifi...

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Bibliographic Details
Main Authors: Amir N Saleem, Yen-Hui Chen, Hwa Jin Baek, Ya-Wen Hsiao, Hong-Wen Huang, Hsiao-Jung Kao, Kai-Ming Liu, Li-Fen Shen, I-Wen Song, Chen-Pei D Tu, Jer-Yuarn Wu, Tateki Kikuchi, Monica J Justice, Jeffrey J Y Yen, Yuan-Tsong Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2883605?pdf=render

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http://europepmc.org/articles/PMC2883605?pdf=render

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