Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.

Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.

BACKGROUND:The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP...

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Main Authors: Wang-Qing Chen, Yan Shu, Qing Li, Lin-Yong Xu, Mary W Roederer, Lan Fan, Lan-Xiang Wu, Fa-Zhong He, Jian-Quan Luo, Zhi-Rong Tan, Yi-Jing He, Hong-Hao Zhou, Xiang Chen, Wei Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3734062?pdf=render

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http://europepmc.org/articles/PMC3734062?pdf=render

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