Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.
BACKGROUND:The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3734062?pdf=render |
| _version_ | 1811322595872604160 |
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| author | Wang-Qing Chen Yan Shu Qing Li Lin-Yong Xu Mary W Roederer Lan Fan Lan-Xiang Wu Fa-Zhong He Jian-Quan Luo Zhi-Rong Tan Yi-Jing He Hong-Hao Zhou Xiang Chen Wei Zhang |
| author_facet | Wang-Qing Chen Yan Shu Qing Li Lin-Yong Xu Mary W Roederer Lan Fan Lan-Xiang Wu Fa-Zhong He Jian-Quan Luo Zhi-Rong Tan Yi-Jing He Hong-Hao Zhou Xiang Chen Wei Zhang |
| author_sort | Wang-Qing Chen |
| collection | DOAJ |
| description | BACKGROUND:The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP change after taking 40 mg telmisartan in 48 healthy Chinese males. METHOD:A total of 48 healthy males were included in this trial. Every volunteer ingested a single dose of 40 mg telmisartan, and the plasma drug concentration and blood pressure (BP) were measured up to 48 h. RESULT:In this study, the area under the plasma concentration-time curve (AUC) in the heterozygotes of ORM1 113AG was higher than that in the wild-type homozygotes, AUC(0-48) (113AA vs. 113AG, 1,549.18±859.84 ng·h/ml vs. 2,313.54±1,257.71 ng·h/ml, P = 0.033), AUC(0-∞) (113AA vs. 113AG, 1,753.13±1,060.60 ng·h/ml vs. 2,686.90±1,401.87 ng·h/ml, P = 0.016), and the change(%) of the diastolic blood pressure (DBP) from the baseline BP value also showed a significant difference between the ORM1 113AG and 113AA genotypes at 5 h after taking telmisartan (P = 0.026). This study also showed that the allele of ABCC2 C3972T would affected the disposition of telmsiartan and the DBP change significantly after taking the drug. However, the common SNPs of ABCG2 C421, ABCB1 C3435T, and SLCO1B3 T334G showed no impacts on the PKs of telmisartan or BP change(%) in our trial. CONCLUSION:The ORM1 A113G polymorphism was associated with the PKs variability after taking telmsiartan, as well as ABCC2 C3972T. The heterozygotes of ORM1 113AG showed a larger AUC and a notable BP change(%) from the baseline compared with the wild-type. TRIAL REGISTRATION:Chinese Clinical Trial Registry ChiCTR-TNC-10000898. |
| first_indexed | 2024-04-13T13:39:02Z |
| format | Article |
| id | doaj.art-4c647e2a453147efbefd72d4520830d7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:39:02Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-4c647e2a453147efbefd72d4520830d72022-12-22T02:44:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7034110.1371/journal.pone.0070341Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.Wang-Qing ChenYan ShuQing LiLin-Yong XuMary W RoedererLan FanLan-Xiang WuFa-Zhong HeJian-Quan LuoZhi-Rong TanYi-Jing HeHong-Hao ZhouXiang ChenWei ZhangBACKGROUND:The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP change after taking 40 mg telmisartan in 48 healthy Chinese males. METHOD:A total of 48 healthy males were included in this trial. Every volunteer ingested a single dose of 40 mg telmisartan, and the plasma drug concentration and blood pressure (BP) were measured up to 48 h. RESULT:In this study, the area under the plasma concentration-time curve (AUC) in the heterozygotes of ORM1 113AG was higher than that in the wild-type homozygotes, AUC(0-48) (113AA vs. 113AG, 1,549.18±859.84 ng·h/ml vs. 2,313.54±1,257.71 ng·h/ml, P = 0.033), AUC(0-∞) (113AA vs. 113AG, 1,753.13±1,060.60 ng·h/ml vs. 2,686.90±1,401.87 ng·h/ml, P = 0.016), and the change(%) of the diastolic blood pressure (DBP) from the baseline BP value also showed a significant difference between the ORM1 113AG and 113AA genotypes at 5 h after taking telmisartan (P = 0.026). This study also showed that the allele of ABCC2 C3972T would affected the disposition of telmsiartan and the DBP change significantly after taking the drug. However, the common SNPs of ABCG2 C421, ABCB1 C3435T, and SLCO1B3 T334G showed no impacts on the PKs of telmisartan or BP change(%) in our trial. CONCLUSION:The ORM1 A113G polymorphism was associated with the PKs variability after taking telmsiartan, as well as ABCC2 C3972T. The heterozygotes of ORM1 113AG showed a larger AUC and a notable BP change(%) from the baseline compared with the wild-type. TRIAL REGISTRATION:Chinese Clinical Trial Registry ChiCTR-TNC-10000898.http://europepmc.org/articles/PMC3734062?pdf=render |
| spellingShingle | Wang-Qing Chen Yan Shu Qing Li Lin-Yong Xu Mary W Roederer Lan Fan Lan-Xiang Wu Fa-Zhong He Jian-Quan Luo Zhi-Rong Tan Yi-Jing He Hong-Hao Zhou Xiang Chen Wei Zhang Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan. PLoS ONE |
| title | Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan. |
| title_full | Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan. |
| title_fullStr | Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan. |
| title_full_unstemmed | Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan. |
| title_short | Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan. |
| title_sort | polymorphism of orm1 is associated with the pharmacokinetics of telmisartan |
| url | http://europepmc.org/articles/PMC3734062?pdf=render |
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