A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects

Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of HSK16149 after single and multiple doses in healthy Chinese subjects.Methods: The randomized, double-blind,...

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Bibliographic Details
Main Authors: Qian Chen, Qingqing Wu, Rong Song, Yating Wang, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
HSK16149
GABA analog
safety
pharmacokinetics
healthy subjects
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1296672/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1296672/full

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