miRNA-381 regulates renal cancer stem cell properties and sunitinib resistance via targeting SOX4

miRNA-381 regulates renal cancer stem cell properties and sunitinib resistance via targeting SOX4

Cancer stem cells (CSCs) are crucial in the pathogenesis of human cancers. Existing studies reported that microRNA (miRNA) modulates the stemness of CSCs. We discovered that renal cell CSCs have suppressed miR-381. Suppression of miR-381 promotes renal cell tumorigenesis and CSC-like properties. Fur...

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Bibliographic Details
Main Authors: Xiao-jun Lu, Wen-wen Gao, Jia-cheng Li, Sheng-Fei Qin
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Cancer stem cell
Renal cell carcinoma
miR-381
SOX4
Sunitinib
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001474

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http://www.sciencedirect.com/science/article/pii/S2405580823001474

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