Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation

Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation

Objective: Melanocortin-4 receptors (MC4Rs) are highly expressed by dopamine-secreting neurons of the mesolimbic tract, but their functional role has not been fully resolved. Voluntary wheel running (VWR) induces adaptations in the mesolimbic dopamine system and has a myriad of long-term beneficial...

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Bibliographic Details
Main Authors: Silvana Obici, I. Jack Magrisso, Armen S. Ghazarian, Alireza Shirazian, Jonas R. Miller, Christine M. Loyd, Denovan P. Begg, Kimberly A. Krawczewski Carhuatanta, Michael K. Haas, Jon F. Davis, Stephen C. Woods, Darleen A. Sandoval, Randy J. Seeley, Laurie J. Goodyear, Emmanuel N. Pothos, Joram D. Mul
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Molecular Metabolism
Subjects:
MC4R
Nucleus accumbens
Voluntary wheel running
Dopamine
Obesity
Diabetes
Food intake
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001374

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http://www.sciencedirect.com/science/article/pii/S2212877815001374

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