Targeting BMI-1-mediated epithelial–mesenchymal transition to inhibit colorectal cancer liver metastasis

Targeting BMI-1-mediated epithelial–mesenchymal transition to inhibit colorectal cancer liver metastasis

Liver is the most common metastatic site for colorectal cancer (CRC), there is no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated the role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulat...

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Bibliographic Details
Main Authors: Zhiyao Xu, Zhuha Zhou, Jing Zhang, Feichao Xuan, Mengjing Fan, Difan Zhou, Zhenyu Liuyang, Ximei Ma, Yiyang Hong, Yihong Wang, Sherven Sharma, Qinghua Dong, Guanyu Wang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
BMI-1
Colorectal cancer
Liver metastasis
Epithelial–mesenchymal transition
Snail
AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308170

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http://www.sciencedirect.com/science/article/pii/S2211383520308170

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