Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts

Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts

Although most fractures heal, critical defects in bone fail due to aberrant differentiation of mesenchymal stem cells towards fibrosis rather than osteogenesis. While conventional bioengineering solutions to this problem have focused on enhancing angiogenesis, which is required for bone formation, r...

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Bibliographic Details
Main Authors: Ben Antebi, Longze Zhang, Dmitriy Sheyn, Gadi Pelled, Xinping Zhang, Zulma Gazit, Edward M. Schwarz, Dan Gazit
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Bioengineering
Subjects:
critical bone defect
arteriogenesis
osteogenesis
fibrosis
mast cells
recombinant parathyroid hormone (rPTH
teriparatide
Forteo)
Online Access:http://www.mdpi.com/2306-5354/3/1/6

Internet

http://www.mdpi.com/2306-5354/3/1/6

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