Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor 2 Expression via Transforming Growth Factor-β

Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor 2 Expression via Transforming Growth Factor-β

ABSTRACT To initiate an antileishmanial adaptive immune response, dendritic cells (DCs) must carry Leishmania antigens from peripheral tissues to local draining lymph nodes. However, the migratory capacity of DCs is largely compromised during Leishmania donovani infection. The molecular mechanism un...

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Bibliographic Details
Main Authors: Manisha Yadav, Md. Naushad Akhtar, Manish Mishra, Sandeep Kumar, Raj Kumar, Shubham, Anil Nandal, Pradip Sen
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
dendritic cell trafficking
CLEC-2
Leishmania donovani
c-Src
TGF-β
NF-κB
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04122-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04122-22

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