Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity

Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity

Abstract Background Novel precision medicine therapeutics target increasingly granular, genomically-defined populations. Rare sub-groups make it challenging to study within a clinical trial or single real-world data (RWD) source; therefore, pooling from disparate sources of RWD may be required for f...

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Bibliographic Details
Main Authors: Daniel Backenroth, Trevor Royce, Jose Pinheiro, Meghna Samant, Olivier Humblet
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Medical Research Methodology
Subjects:
Pooling
Meta-analysis
Real-world data
Oncology
Small population
Heterogeneity
Online Access:https://doi.org/10.1186/s12874-023-02002-7

Internet

https://doi.org/10.1186/s12874-023-02002-7

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