Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity
Abstract Background Novel precision medicine therapeutics target increasingly granular, genomically-defined populations. Rare sub-groups make it challenging to study within a clinical trial or single real-world data (RWD) source; therefore, pooling from disparate sources of RWD may be required for f...
Main Authors: | Daniel Backenroth, Trevor Royce, Jose Pinheiro, Meghna Samant, Olivier Humblet |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-08-01
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Series: | BMC Medical Research Methodology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12874-023-02002-7 |
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