Urinary Exosomal and cell-free DNA Detects Somatic Mutation and Copy Number Alteration in Urothelial Carcinoma of Bladder

Urinary Exosomal and cell-free DNA Detects Somatic Mutation and Copy Number Alteration in Urothelial Carcinoma of Bladder

Abstract Urothelial bladder carcinoma (UBC) is characterized by a large number of genetic alterations. DNA from urine is a promising source for liquid biopsy in urological malignancies. We aimed to assess the availability of cell-free DNA (cfDNA) and exosomal DNA (exoDNA) in urine as a source for li...

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Bibliographic Details
Main Authors: Dong Hyeon Lee, Hana Yoon, Sanghui Park, Jeong Seon Kim, Young-Ho Ahn, Kihwan Kwon, Donghwan Lee, Kwang Hyun Kim
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Scientific Reports
Subjects:
Somatic Mutation Analysis
Urinary Exosomes
Copy Number Aberrations
Liquid Biopsy
Normal Blood Samples
Online Access:https://doi.org/10.1038/s41598-018-32900-6

Internet

https://doi.org/10.1038/s41598-018-32900-6

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