Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction

Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction

Abstract Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA). Molecular docking studies were done in the allosteric site of t...

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Bibliographic Details
Main Authors: Saurabh C. Khadse, Nikhil D. Amnerkar, Manasi U. Dave, Deepak K. Lokwani, Ravindra R. Patil, Vinod G. Ugale, Nitin B. Charbe, Vivekanand A. Chatpalliwar
Format: Article
Language:English
Published: SpringerOpen 2019-12-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Glucokinase activator
Glucokinase
Quinazolinones
Docking
Online Access:https://doi.org/10.1186/s43094-019-0012-y

Internet

https://doi.org/10.1186/s43094-019-0012-y

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