Immunocompromised Cas9 transgenic mice for rapid in vivo assessment of host factors involved in highly pathogenic virus infection

Immunocompromised Cas9 transgenic mice for rapid in vivo assessment of host factors involved in highly pathogenic virus infection

Targeting host factors for anti-viral development offers several potential advantages over traditional countermeasures that include broad-spectrum activity and prevention of resistance. Characterization of host factors in animal models provides strong evidence of their involvement in disease pathoge...

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Bibliographic Details
Main Authors: Nicole Collette, Pragyesh Dhungel, Sean J. Lund, Jennifer L. Schwedler, Edwin A. Saada, Yooli K. Light, Anupama Sinha, Joseph S. Schoeniger, Oscar A. Negrete
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CRISPR
genome editing
lipid nanoparticles
Ebola virus
NPC1
in vivo delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001509

Internet

http://www.sciencedirect.com/science/article/pii/S2329050121001509

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