MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis

We previously demonstrated that antisense oligonucleotide-mediated knockdown of Mboat7, the gene encoding membrane bound O-acyltransferase 7, in the liver and adipose tissue of mice promoted high fat diet-induced hepatic steatosis, hyperinsulinemia, and systemic insulin resistance. Thereafter, other...

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Bibliographic Details
Main Authors: William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, Bryan M. Jung, Yunguang Qiu, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende, Belinda Willard, Feixiong Cheng, Aldons J. Lusis, J. Mark Brown
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Lipid Research
Subjects:
non-alcoholic fatty liver disease
obesity
metabolism
diabetes
hyperinsulinemia
systemic insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000226

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http://www.sciencedirect.com/science/article/pii/S0022227523000226

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