De novo-designed transmembrane domains tune engineered receptor functions

De novo-designed transmembrane domains tune engineered receptor functions

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs that self-assemble through computationally defined...

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Bibliographic Details
Main Authors: Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie V Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel J Fleishman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
de novo design
membrane protein
transmembrane
chimeric antigen receptor
CAR T cell
immunotherapy
Online Access:https://elifesciences.org/articles/75660

Internet

https://elifesciences.org/articles/75660

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